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These are the Billboard magazine Hot Dance Airplay number one hits of 2010.

Note that Billboard publishes charts with an issue date approximately 7–10 days in advance.

Issue Date Song Artist Remixer(s)
January 2 "Hang On" Plumb Dave Audé, Digital Dog, Bronleewe & Bose
January 9 "Hot" Inna Play & Win
January 16 "Tik Tok" Kesha Fred Falke
January 23 "Tik Tok" Kesha
January 30 "Hot" Inna
February 6 "Tik Tok" Kesha
February 13 "Tik Tok" Kesha
February 20 "Tik Tok" Kesha
February 27 "Bad Romance" Lady Gaga Hercules & Love Affair, Kaskade, Bimbo Jones, Starsmith, Richard Vission, DJ Dan, Skrillex, Grum, Chew Fu
March 6 "Secret Love" Kim Sozzi Josh Harris, Wendel Kos, Stellar Project
March 13 "Love Keeps Calling" AnnaGrace Basto, Lucky Charmes & Tony Verdult
March 20 "Love Keeps Calling" AnnaGrace
March 27 "Love Keeps Calling" AnnaGrace
April 3 "Secret Love" Kim Sozzi
April 10 "Heartbreak" M'Black Felix Baumgartner, Ron May, Inner Smile, Caged Baby
April 17 "Heartbreak" M'Black
April 24 "Sweet Disposition" The Temper Trap Axwell, Dirty South
May 1 "Rude Boy" Rihanna Wideboys, Jonathan Peters, Chew Fu, Low Sunday
May 8 "Break Your Heart" Taio Cruz featuring Ludacris Paul Thomas, Vito Benito
May 15 "Ghosts N Stuff" Deadmau5 featuring Rob Swire
May 22 "Heartbreak on Vinyl" Blake Lewis Bimbo Jones, LA Riots, Chew Fu
May 29 "Naturally" Selena Gomez & the Scene Dave Audé, Ralphi Rosario, Disco Fries
June 5 "Stereo Love" Edward Maya & Vika Jigulina Molella, DaBo
June 12 "Happiness" Alexis Jordan Wideboys
June 19 "Gettin' Over You" David Guetta & Chris Willis Featuring Fergie & LMFAO
June 26 "Stereo Love" Edward Maya & Vika Jigulina
July 3 "Gettin' Over You" David Guetta & Chris Willis Featuring Fergie & LMFAO
July 10 "California Gurls" Katy Perry Featuring Snoop Dogg
July 17 "California Gurls" Katy Perry Featuring Snoop Dogg
July 24 "California Gurls" Katy Perry Featuring Snoop Dogg
July 31 "Cooler Than Me" Mike Posner Gigamesh
August 7 "Dynasty" Kaskade featuring Haley Michael Woods, Dada Life, Ryan Marciano & Sunnery James
August 14 "Better Than Her" Matisse
August 21 "Dynamite" Taio Cruz Mixin' Marc, Stonebridge, Ralphi Rosario
August 28[1] "The Radio" Get Far Featuring H-Boogie

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